Jun XIA - BRAIN AND INTELLIGENCE RESEARCH INSTITUTE

夏军教授于1993年在中南大学湘雅医学院完成医学培训，随后在中国科学院上海脑研究所完成初步科学训练后，他前往美国约翰霍普金斯大学医学院继续深造，并于2001年获得神经科学博士学位。夏军教授自2002年起加入香港科技大学，成为该校的教职人员。夏军教授的研究兴趣主要集中在突触的结构与功能，及其在学习、记忆和脑部疾病中的影响，他还研究蛋白质运输的分子机制及其在疾病中的作用。他的研究发现PICK1是蛋白质运输的关键调节因子。PICK1与ICA69形成异源BAR结构域复合物，调节AMPA受体在突触的运输，这对突触功能至关重要。此外，PICK1-ICA69复合物还调控致密核心囊泡（如胰岛素颗粒和前极体颗粒）的生成和成熟。在小鼠中缺乏PICK1会导致葡萄糖耐受性下降及其他类似糖尿病的特征。

研究领域

学习与记忆

脑部疾病机制研究

突触形成与功能

蛋白质运输

论文发表

Zheng R, Du Y, Wang X, Liao T, Zhang Z, Wang N, Li X, Shen Y, Shi L, Luo J, Xia J, Wang Z, Xu J (2022). KIF2C regulates synaptic plasticity and cognition in mice through dynamic microtubule depolymerization. eLife 11:e72483.*Co-corresponding authors

He J, Xia M, Yeung PKK, Li J, Li, Z, Chung KK, Chung SK, Xia J* (2018) PICK1 inhibits the E3 ubiquitin ligase activity of Parkin and reduces its neuronal protective effect. PNAS 115(30):E7193-E7201

Wu M, Tian HL, Liu X, Lai JHC, Du S, Xia J* (2018) Impairments of Inhibitory Synapse Formation and Motor Behaviors in Mice Lacking the NL2 Binding Partner LHFPL4/GARLH4. Cell Reports 23:1691-1705.

Xu J, Kam C, Luo J, Xia J. (2014) PICK1 Mediates Synaptic Recruitment of AMPA Receptors at Neurexin-induced Postsynaptic Sites. Neurosci.* 34(46):15415-15424

Cao M, Mao Z, Kam C, Xiao N, Cao X, Shen C, Cheng KKY, Xu A, Lee KM, Jiang L and Xia J* (2013). PICK1 and ICA69 Control Insulin Granule Trafficking and Their Deficiencies Lead to Impaired Glucose Tolerance. PLOS Biology, 11(4): e1001541.

Xu J, Xiao N, Xia J* (2010). Thrombospondin 1 accelerates synaptogenesis in hippocampal neurons through neuroligin 1. Neurosci. 13(1):22-4.

Xiao N, Kam C, Shen C, Jin W, Wang J, Lee KM, Jiang L and Xia J* (2009). PICK1 deficiency causes male infertility in mice by disrupting acrosome formation. Clin Invest. 119(4):802-812.

Pan L, Wu H, Shen C, Shi Y, Jin W, Xia Jand Zhang M (2007). Clustering and synaptic targeting of PICK1 requires direct interaction between the PDZ domain and lipid membranes. EMBO J. 26(21):4576-87 *Co-corresponding authors.

Cao M, Xu J, Shen C, Kam C, Huganir RL and Xia J* (2007). PICK1-ICA69 heteromeric BAR domain complex regulates synaptic targeting and surface expression of AMPA receptors. Neurosci. 27(47):12945-12956.

Jin W, Ge W, Xu J, Cao M, Peng L, Yung W, Liao D, Duan S, Zhang M and Xia J* (2006). Lipid Binding Regulates PICK1’s Synaptic Targeting, AMPA Receptor Trafficking and Synaptic Plasticity. Neurosci. 26(9):2380-2390

Xia J, Chung HJ, Wihler C, Huganir RL and Linden DJ (2000). Cerebellar Long-Term Depression Requires PKC Regulated Interactions Between GluR2/3 and PDZ Domain-Containing Proteins. Neuron, 28(2):499-510.

Xia J, Zhang X, Staudinger J, Huganir RL. (1999). Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1. Neuron 22(1):179-87.

个人简介