Li TAO - BRAIN AND INTELLIGENCE RESEARCH INSTITUTE

团队

陶莉

生物化学与分子生物学博士

北京协和医学院/北京生命科学研究所，2012

助理教授

生物科学与生物医学工程学域

研究团队

litao@hkust-gz.edu.cn

E4(C9) L4 406

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个人简介

Dr. Li Tao is an assistant professor in the Bioscience and Biomedical Engineering (BSBE) Thrust, Systems Hub, HKUST (Guangzhou), and The Brain and Intelligence Research Institute. She obtained her Ph.D. from Peking Union Medical College/Tsinghua University, where she studied the aging process using quantitative proteomics. Dr. Li Tao then conducted her postdoctoral research at Stanford University/HHMI, focusing on studying neuronal development and functions at the cellular level. In 2023, Dr. Li Tao joined the Hong Kong University of Science and Technology (Guangzhou) with research interests centered around understanding the molecular mechanisms that regulate neural development and neurotransmission in normal and age-related disease states. She plans to combine multiple strategies, including genome editing, live-cell imaging, behavioral assays, and large high-throughput proteomics to identify novel regulators that involved in neuronal development and neurological diseases, especially neurodegenerative disorders.

研究领域

Neuronal cell biology

Neuronal morphogenisis

Neurotransmission

Aging

论文发表

Tao, L., Coakley, S., Shi, R., & Shen, K. (2022). Dendrites use mechanosensitive channels to proofread ligand-mediated neurite extension during morphogenesis. Developmental Cell, 57(13), 1615-1629.

Li, W. J., Wang, C. W., Tao, L., Yan, Y. H., Zhang, M. J., Liu, Z. X., … & Dong, M. Q. (2021). Insulin signaling regulates longevity through protein phosphorylation in Caenorhabditis elegans. Nature communications, 12(1), 4568.

Tao, L., Porto, D., Li, Z., Fechner, S., Lee, S. A., Goodman, M. B., … & Shen, K. (2019). Parallel processing of two mechanosensory modalities by a single neuron in C. elegans. Developmental cell, 51(5), 617-631.

Niwa, S., Tao, L., Lu, S. Y., Liew, G. M., Feng, W., Nachury, M. V., & Shen, K. (2017). BORC regulates the axonal transport of synaptic vesicle precursors by activating ARL-8. Current Biology, 27(17), 2569-2578.

Tao, L., Xie, Q., Ding, Y. H., Li, S. T., Peng, S., Zhang, Y. P., … & Dong, M. Q. (2013). CAMKII and calcineurin regulate the lifespan of Caenorhabditis elegans through the FOXO transcription factor DAF-16. Elife, 2, e00518.

Fechner, S., D’Alessandro, I., Wang, L., Tower, C., Tao, L., & Goodman, M. B. (2021). DEG/ENaC/ASIC channels vary in their sensitivity to anti-hypertensive and non-steroidal anti-inflammatory drugs. The Journal of General Physiology, 153(4).

Shi, R., Ho, X. Y., Tao, L., Taylor, C. A., Zhao, T., Zou, W., … & Shen, K. (2024). Stochastic growth and selective stabilization generate stereotyped dendritic arbors. bioRxiv, 2024-05.

McDonald, N. A., Tao, L., Dong, M. Q., & Shen, K. (2023). SAD-1 kinase controls presynaptic phase separation by relieving SYD-2/Liprin-α autoinhibition. PLoS biology, 21(12), e3002421.

Fechner, S., D’Alessandro, I., Wang, L., Tower, C., Tao, L., & Goodman, M. B. (2020). Functional and pharmacological characterization of C. elegans DEG/ENaC/ASIC channels. Biophysical Journal, 118(3), 114a.

Tan, D., Li, Q., Zhang, M. J., Liu, C., Ma, C., Zhang, P., … & Lei, X. (2016). Trifunctional cross-linker for mapping protein-protein interaction networks and comparing protein conformational states. Elife, 5, e12509.

Xie, Q., Peng, S., Tao, L., Ruan, H., Yang, Y., Li, T. M., … & Yuan, Z. (2014). E2F transcription factor 1 regulates cellular and organismal senescence by inhibiting Forkhead box O transcription factors. Journal of Biological Chemistry, 289(49), 34205-34213.

Qu, M., Yang, B., Tao, L., Yates III, J. R., Russell, P., Dong, M. Q., & Du, L. L. (2012). Phosphorylation-dependent interactions between Crb2 and Chk1 are essential for DNA damage checkpoint. PLoS genetics, 8(7), e1002817.

Xie, Q., Hao, Y., Tao, L., Peng, S., Rao, C., Chen, H., … & Yuan, Z. (2012). Lysine methylation of FOXO3 regulates oxidative stress‐induced neuronal cell death. EMBO reports, 13(4), 371-377.

Sun, R. X., Dong, M. Q., Song, C. Q., Chi, H., Yang, B., Xiu, L. Y., … & He, S. M. (2010). Improved peptide identification for proteomic analysis based on comprehensive characterization of electron transfer dissociation spectra. Journal of Proteome Research, 9(12), 6354-6367.