团队
梁卓毅

生命科学博士

香港科技大学,2015

助理教授

生物科学与生物医学工程学域

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个人简介

梁卓毅博士,本科毕业于上海交通大学,在香港科技大学获得生命科学博士学位,毕业后在哈佛医学院-波士顿儿童医院进行博士后研究,继而担任哈佛医学院讲师。现加入香港科技大学广州校区担任助理教授。其研究主要集中在分子神经学、免疫学和基因组学,成果发表于Nature, Nature communications, PNAS, Nature Protocols及Journal of Neuroscience。

 
研究领域

Neuroscience

Immunology

Genomic instability

Cancer

Neurodegenerative diseases

论文发表

Liang Z, Zhao L, Ye AY, Lin SG, Zhang Y, Guo C, Dai HQ, Ba Z, Alt FW. Contribution of the IGCR1 regulatory element and the 3’Igh CTCF-binding elements to regulation of Igh V(D)J recombination. Proc Natl Acad Sci U S A. 2023 Jun 27;120(26):e2306564120. doi: 10.1073/pnas.2306564120. Epub 2023 Jun 20. PMID: 37339228; PMCID: PMC10293834.

Dong Y, Pi X, Bartels-Burgahn F, Saltukoglu D, Liang Z, Yang J, Alt FW, Reth M, Wu H. Structural principles of B cell antigen receptor assembly. Nature. 2022 Dec;612(7938):156-161. doi: 10.1038/s41586-022-05412-7. Epub 2022 Oct 13. PMID: 36228656.

Liang Z, Kumar V, Le Bouteiller M, Zurita J, Kenrick J, Lin SG, Lou J, Hu J, Ye AY, Boboila C, Alt FW, Frock RL. Ku70 suppresses alternative end joining in G1-arrested progenitor B cells. Proc Natl Acad Sci U S A. 2021 May 25;118(21):e2103630118. doi: 10.1073/pnas.2103630118. PMID: 34006647; PMCID: PMC8166026.

Dai HQ, Liang Z, Chang AN, Chapdelaine-Williams AM, Alvarado B, Pollen AA, Alt FW, Schwer B. Direct analysis of brain phenotypes via neural blastocyst complementation. Nat Protoc. 2020 Oct;15(10):3154-3181. doi: 10.1038/s41596-020-0364-y. Epub 2020 Aug 10. PMID: 32778838; PMCID: PMC7685531.

Zhang Y, Zhang X, Ba Z, Liang Z, Dring EW, Hu H, Lou J, Kyritsis N, Zurita J, Shamim MS, Presser Aiden A, Lieberman Aiden E, Alt FW. The fundamental role of chromatin loop extrusion in physiological V(D)J recombination. Nature. 2019 Sep;573(7775):600-604. doi: 10.1038/s41586-019-1547-y. Epub 2019 Sep 11. PMID: 31511698; PMCID: PMC6867615.

Chang AN, Liang Z, Dai HQ, Chapdelaine-Williams AM, Andrews N, Bronson RT, Schwer B, Alt FW. Neural blastocyst complementation enables mouse forebrain organogenesis. Nature. 2018 Nov;563(7729):126-130. doi: 10.1038/s41586-018-0586-0. Epub 2018 Oct 10. PMID: 30305734; PMCID: PMC6588192.

Chen C, Liang Z, Zhou B, Li X, Lui C, Ip NY, Qu JY. In Vivo Near-Infrared Two-Photon Imaging of Amyloid Plaques in Deep Brain of Alzheimer’s Disease Mouse Model. ACS Chem Neurosci. 2018 Dec 19;9(12):3128-3136. doi: 10.1021/acschemneuro.8b00306. Epub 2018 Aug 16. PMID: 30067906.

Huang H, Lin X, Liang Z, Zhao T, Du S, Loy MMT, Lai KO, Fu AKY, Ip NY. Cdk5-dependent phosphorylation of liprinα1 mediates neuronal activity-dependent synapse development. Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):E6992-E7001. doi: 10.1073/pnas.1708240114. Epub 2017 Jul 31. Erratum in: Proc Natl Acad Sci U S A. 2017 Oct 23;: PMID: 28760951; PMCID: PMC5565463.

Liang Z, Zhan Y, Shen Y, Wong CC, Yates JR 3rd, Plattner F, Lai KO, Ip NY. The pseudokinase CaMKv is required for the activity-dependent maintenance of dendritic spines. Nat Commun. 2016 Oct 31;7:13282. doi: 10.1038/ncomms13282. PMID: 27796283; PMCID: PMC5095516.

Liang Z, Ye T, Zhou X, Lai KO, Fu AK, Ip NY. Cdk5 Regulates Activity-Dependent Gene Expression and Dendrite Development. J Neurosci. 2015 Nov 11;35(45):15127-34. doi: 10.1523/JNEUROSCI.1443-15.2015. Erratum in: J Neurosci. 2016 Jan 6;36(1):262. PMID: 26558783; PMCID: PMC6605353.

Lai KO, Liang Z, Fei E, Huang H, Ip NY. Cyclin-dependent Kinase 5 (Cdk5)-dependent Phosphorylation of p70 Ribosomal S6 Kinase 1 (S6K) Is Required for Dendritic Spine Morphogenesis. J Biol Chem. 2015 Jun 5;290(23):14637-46. doi: 10.1074/jbc.M114.627117. Epub 2015 Apr 22. PMID: 25903132; PMCID: PMC4505530.

Chen Y, Liang Z, Fei E, Chen Y, Zhou X, Fang W, Fu WY, Fu AK, Ip NY. Axin Regulates Dendritic Spine Morphogenesis through Cdc42-Dependent Signaling. PLoS One. 2015 Jul 23;10(7):e0133115. doi: 10.1371/journal.pone.0133115. PMID: 26204446; PMCID: PMC4512687.

Lai KO, Wong AS, Cheung MC, Xu P, Liang Z, Lok KC, Xie H, Palko ME, Yung WH, Tessarollo L, Cheung ZH, Ip NY. TrkB phosphorylation by Cdk5 is required for activity-dependent structural plasticity and spatial memory. Nat Neurosci. 2012 Nov;15(11):1506-15. doi: 10.1038/nn.3237. Epub 2012 Oct 14. PMID: 23064382; PMCID: PMC7511999.