团队
沈阳

生物化学博士

香港科技大学,2014

助理教授

生物科学与生物医学工程学域

ResearcherID:
Scopus:
Google Scholar:

gmfkIrIAAAAJ

ORCID:

0000-0002-6055-5046

个人简介

沈阳,博士,助理教授。本科毕业于上海交通大学生物工程专业,随后在香港科技大学获得生物化学博士学位。此后,于加州大学洛杉矶分校从事博士后研究,并担任助理研究员。2024年加入香港科技大学(广州)担任助理教授,在脑与智能研究所开展研究。

实验室聚焦于学习和记忆过程的分子与细胞机制,致力于开发针对衰老或神经退行性疾病引发的认知障碍的诊断和治疗策略。

 
研究领域

记忆的编码与存储
神经元与小胶质细胞的相互作用
突触可塑性
衰老与神经退行性疾病

论文发表

Shen Y, Zhou M, Cai D, Filho DA, Fernandes G, Cai Y, de Sousa AF, Tian M, Kim N, Lee J, Necula D, Zhou C, Li S, Salinas S, Liu A, Kang X, Kamata M, Lavi A, Huang S, Silva T, Heo WD, Silva AJ. CCR5 closes the temporal window for memory linking. Nature. 2022 Jun;606(7912):146-152. doi: 10.1038/s41586-022-04783-1. Epub 2022 May 25. PMID: 35614219; PMCID: PMC9197199.

Shen Y, Tian M, Zheng Y, Gong F, Fu AKY, Ip NY. Stimulation of the Hippocampal POMC/MC4R Circuit Alleviates Synaptic Plasticity Impairment in an Alzheimer’s Disease Model. Cell Rep. 2016 Nov 8;17(7):1819-1831. doi: 10.1016/j.celrep.2016.10.043. PMID: 27829153.

Shen Y, Fu WY, Cheng EY, Fu AK, Ip NY. Melanocortin-4 receptor regulates hippocampal synaptic plasticity through a protein kinase A-dependent mechanism. J Neurosci. 2013 Jan 9;33(2):464-72. doi: 10.1523/JNEUROSCI.3282-12.2013. PMID: 23303927; PMCID: PMC6704894.

Sehgal, D. A. Filho, G. Kastellakis, S. Kim, J. Lee, Y Shen, S. Huang, A. Lavi, G. Fernandes, S. S. Martin, I. D. Mejia, A. Pekcan, M. S. Wu, W. D. Heo, P. Poirazi, J. T. Trachtenberg, A. J Silva. Compartmentalized dendritic plasticity in the retrosplenial cortex integrates memories. Nature neuroscience. 2024, in press.

Huang HY, Salinas S, Cornell J, Udoh IB, Shen Y, Zhou M. CCR5 regulates Aβ1-42-induced learning and memory deficits in mice. Neurobiol Learn Mem. 2024 Feb;208:107890. doi: 10.1016/j.nlm.2024.107890. Epub 2024 Jan 11. PMID: 38215963.

Lau JKY, Tian M, Shen Y, Lau SF, Fu WY, Fu AKY, Ip NY. Melanocortin receptor activation alleviates amyloid pathology and glial reactivity in an Alzheimer’s disease transgenic mouse model. Sci Rep. 2021 Feb 23;11(1):4359. doi: 10.1038/s41598-021-83932-4. PMID: 33623128; PMCID: PMC7902646.

Liang Z, Zhan Y, Shen Y, Wong CC, Yates JR 3rd, Plattner F, Lai KO, Ip NY. The pseudokinase CaMKv is required for the activity-dependent maintenance of dendritic spines. Nat Commun. 2016 Oct 31;7:13282. doi: 10.1038/ncomms13282. PMID: 27796283; PMCID: PMC5095516.

Li S, He Q, Wang H, Tang X, Ho KW, Gao X, Zhang Q, Shen Y, Cheung A, Wong F, Wong YH, Ip NY, Jiang L, Yung WH, Liu K. Injured adult retinal axons with Pten and Socs3 co-deletion reform active synapses with suprachiasmatic neurons. Neurobiol Dis. 2015 Jan;73:366-76. doi: 10.1016/j.nbd.2014.09.019. Epub 2014 Oct 16. PMID: 25448764.

Fu AK, Hung KW, Huang H, Gu S, Shen Y, Cheng EY, Ip FC, Huang X, Fu WY, Ip NY. Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer’s disease. Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9959-64. doi: 10.1073/pnas.1405803111. Epub 2014 Jun 23. PMID: 24958880; PMCID: PMC4103318.