https://scholar.google.com/citations?user=bCQH8WcAAAAJ&hl=en
个人简介
田博士是香港科技大学（广州）系统枢纽生物科学与生物医学工程领域的助理教授，并同时兼任脑与智能研究所的研究职务。她本科毕业于四川大学华西医学中心，获理学学士学位；随后在北京大学医学部获得理学硕士学位。田博士在香港科技大学完成了博士学位，师从叶玉如教授。之后，她前往加州大学洛杉矶分校David·Geffen医学院，在S. Thomas Carmichael教授的实验室从事博士后研究，并晋升为助理项目科学家。
研究领域
田博士的研究聚焦于阐释以多种类型痴呆为代表的神经退行性疾病中损伤与修复过程所涉及的分子、细胞及神经环路机制。通过整合人类及模式动物的细胞类型特异性转录组学、生物信息学、行为学实验及体内基因操作技术，她发现了参与神经血管功能障碍与修复过程的内皮细胞与胶质细胞亚群之间关键的通路交互信号传导机制。其研究已揭示了多个具有前景的治疗靶点，包括Serpine2-Lrp1与CD39-A3AR信号轴等，并利用小分子药物开发、基因治疗及高通量筛选平台等多种手段对其功能进行了系统验证。在基础机制发现之外，田博士积极推动相关转化研究，通过与药物化学专家及临床医生开展合作，致力于推动新型痴呆治疗药物的研发。
Tian M * (Corresponding author), Llorente IL, Carmichael ST *. Protocol for mouse vascular dementia model and evaluation of progressive tissue damage. Star Protocols (2026). * Corresponding author
Tian M, Kawaguchi R, Shen Y, Machnicki M, Villegas NG, Cooper DR, Cai Y, Montgomery N, Haring J, Lan R, Yuan AH, Williams CK, Magaki S, Vinters HV, Zhang Y, De Biase LM, Silva AJ, Carmichael ST. Deconstructing the intercellular interactome in vascular dementia with focal ischemia for therapeutic applications. Cell (2025) DOI: 10.1016/j.cell.2025.06.002
Li J, Godoy MI, Lu Y, Zhang AJ, Diamante G, Rathbun E, Tian M, Ahn IS, Cebrian-Silla A, Alvarez-Buylla A, Yang X, Novitch BG, Carmichael ST, Zhang Y. Molecular regulation of the time span of neurogenesis and the postnatal disappearance of embryonic radial glia. Nature Communications (2025) 16, 6659. DOI: 10.1038/s41467-025-60895-y
Mitroi DN, Tian M, Kawaguchi R, Lowry WE, Carmichael ST. Single-nucleus transcriptome analysis reveals disease- and regeneration-associated endothelial cells in white matter vascular dementia. Journal of Cellular and Molecular Medicine (2022) 00:1-13. DOI: 10.1111/jcmm.17315
Shen Y, Zhou M, Cai D, Filho DA, Fernandes G, Cai Y, Sousa A, Tian M, Kim N, Lee J, Necula D, Zhou C, Li S, Salinas S, Liu A, Kang X, Kamata M, Lavi A, Huang S, Silva T, Heo WD, Silva AJ. CCR5 closes the temporal window for memory linking. Nature (2022).
Lau J#, Tian M#, Shen Y, Lau SF, Fu WY, Fu AKY, Ip Nancy. Melanocortin receptor activation alleviates amyloid pathology and glial reactivity in an Alzheimer’s disease transgenic mouse model. Scientific Reports (2021). 11:4359. # Co-first authors.
Shen Y, Tian M, Zheng YQ, Fei G, Fu AKY, Ip Nancy. Stimulation of the hippocampal POMC/MC4R circuit alleviates synaptic plasticity impairment in an Alzheimer’s disease model. Cell Reports (2016). 17(7):1819-31.
Li XW, Morinaga O, Tian M, Uto T, Yu J, Shang MY, Wang X, Cai SQ, Shoyama Y. Development of an Eastern blotting technique for the visual detection of aristolochic acids in Aristolochia and Asarum species by using a monoclonal antibody against aristolochic acids I and II. Phytochemical Analysis (2013). 24(6):645-53.
Shang MY, Tian M, Tanaka H, Li XW, Cai SQ, Shoyama Y. Quality control of traditional Chinese medicine by monoclonal antibody method. Current Drug Discovery Technologies (2011). 8(1):60-5.
Li YL, Tian M, Yu J, Shang MY, Cai SQ. Studies on morphology and aristolochic acid analogue constituents of Asarum campaniflorum and a comparison with two official species of Asari radix et rhizoma. Journal of Nature Medicines (2010). Oct;64(4):442-51
Tian M, Tanaka H, Shang MY, Karashima S, Chao Z, Wang X, Cai SQ, Shoyama Y. Production, Characterization of a Monoclonal Antibody against Aristolochic Acid-II and Development of Its Assay System. American Journal of Chinese Medicine (2008). 36 (2): 425-36