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Yang SHEN

PhD in Biochemistry

Hong Kong University of Science and Technology, 2014

Assistant Professor

Thrust of Bioscience and Biomedical Engineering
Division of Life Science

Lab Home Page
E4(C9) L5 507
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ORCID:

0000-0002-6055-5046

Biography

Dr. Yang Shen is an assistant professor in Bioscience and Biomedical Engineering (BSBE) Thrust, Systems Hub, HKUST (GZ), and in The Brain and Intelligence Research Institute. Dr. Shen obtained his bachelor’s degree in Bio-engineering from Shanghai Jiao Tong University and received his Ph.D. degree in Biochemistry from The Hong Kong University of Science & Technology. Then he worked as a postdoctoral research fellow and then assistant project scientist at University of California, Los Angeles. In 2024, Dr. Shen joined the Hong Kong University of Science and Technology (Guangzhou).

Dr. Shen’s major research interests focus on understanding the molecular and cellular mechanisms underlying learning and memory processes and developing diagnostic and therapeutic strategies for cognitive deficits caused by aging or neurodegenerative disease.

Research
Interests

Memory encoding and storage
Neuron-microglia crosstalk
Synaptic plasticity
Aging and neurodegeneration

Publications

Shen Y, Zhou M, Cai D, Filho DA, Fernandes G, Cai Y, de Sousa AF, Tian M, Kim N, Lee J, Necula D, Zhou C, Li S, Salinas S, Liu A, Kang X, Kamata M, Lavi A, Huang S, Silva T, Heo WD, Silva AJ. CCR5 closes the temporal window for memory linking. Nature. 2022 Jun;606(7912):146-152. doi: 10.1038/s41586-022-04783-1. Epub 2022 May 25. PMID: 35614219; PMCID: PMC9197199.

Shen Y, Tian M, Zheng Y, Gong F, Fu AKY, Ip NY. Stimulation of the Hippocampal POMC/MC4R Circuit Alleviates Synaptic Plasticity Impairment in an Alzheimer’s Disease Model. Cell Rep. 2016 Nov 8;17(7):1819-1831. doi: 10.1016/j.celrep.2016.10.043. PMID: 27829153.

Shen Y, Fu WY, Cheng EY, Fu AK, Ip NY. Melanocortin-4 receptor regulates hippocampal synaptic plasticity through a protein kinase A-dependent mechanism. J Neurosci. 2013 Jan 9;33(2):464-72. doi: 10.1523/JNEUROSCI.3282-12.2013. PMID: 23303927; PMCID: PMC6704894.

Sehgal, D. A. Filho, G. Kastellakis, S. Kim, J. Lee, Y Shen, S. Huang, A. Lavi, G. Fernandes, S. S. Martin, I. D. Mejia, A. Pekcan, M. S. Wu, W. D. Heo, P. Poirazi, J. T. Trachtenberg, A. J Silva. Compartmentalized dendritic plasticity in the retrosplenial cortex integrates memories. Nature neuroscience. 2024, in press.

Huang HY, Salinas S, Cornell J, Udoh IB, Shen Y, Zhou M. CCR5 regulates Aβ1-42-induced learning and memory deficits in mice. Neurobiol Learn Mem. 2024 Feb;208:107890. doi: 10.1016/j.nlm.2024.107890. Epub 2024 Jan 11. PMID: 38215963.

Lau JKY, Tian M, Shen Y, Lau SF, Fu WY, Fu AKY, Ip NY. Melanocortin receptor activation alleviates amyloid pathology and glial reactivity in an Alzheimer’s disease transgenic mouse model. Sci Rep. 2021 Feb 23;11(1):4359. doi: 10.1038/s41598-021-83932-4. PMID: 33623128; PMCID: PMC7902646.

Liang Z, Zhan Y, Shen Y, Wong CC, Yates JR 3rd, Plattner F, Lai KO, Ip NY. The pseudokinase CaMKv is required for the activity-dependent maintenance of dendritic spines. Nat Commun. 2016 Oct 31;7:13282. doi: 10.1038/ncomms13282. PMID: 27796283; PMCID: PMC5095516.

Li S, He Q, Wang H, Tang X, Ho KW, Gao X, Zhang Q, Shen Y, Cheung A, Wong F, Wong YH, Ip NY, Jiang L, Yung WH, Liu K. Injured adult retinal axons with Pten and Socs3 co-deletion reform active synapses with suprachiasmatic neurons. Neurobiol Dis. 2015 Jan;73:366-76. doi: 10.1016/j.nbd.2014.09.019. Epub 2014 Oct 16. PMID: 25448764.

Fu AK, Hung KW, Huang H, Gu S, Shen Y, Cheng EY, Ip FC, Huang X, Fu WY, Ip NY. Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer’s disease. Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9959-64. doi: 10.1073/pnas.1405803111. Epub 2014 Jun 23. PMID: 24958880; PMCID: PMC4103318.