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Zhuoyi LIANG

PhD in Life Science

Hong Kong University of Science and Technology, 2015

Assistant Professor

Thrust of Bioscience and Biomedical Engineering

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0000-0003-1622-524X

Biography

Dr. Liang is an assistant professor in Bioscience and Biomedical Engineering (BSBE) Thrust, Systems Hub, HKUST (GZ), and in The Brain and Intelligence Research Institute. Dr. Liang received his bachelor’s degree from Shanghai Jiao Tong University and his Ph.D. degree from The Hong Kong University of Science and Technology with Dr. Nancy Y. Ip. He joined Dr. Frederick W. Alt’s laboratory at Boston Children’s Hospital as a postdoc and became an instructor of Harvard Medical School. Dr. Liang’s major research interests focus on the mechanisms of genomic instability in mammalian cells. He has developed new high throughput genomics and animal modeling approaches to study mechanisms that promote and prevent genetic translocations which can lead to cancers and other diseases.

Research
Interests

Neuroscience

Immunology

Genomic instability

Cancer

Neurodegenerative diseases

Publications

Liang Z, Zhao L, Ye AY, Lin SG, Zhang Y, Guo C, Dai HQ, Ba Z, Alt FW. Contribution of the IGCR1 regulatory element and the 3’Igh CTCF-binding elements to regulation of Igh V(D)J recombination. Proc Natl Acad Sci U S A. 2023 Jun 27;120(26):e2306564120. doi: 10.1073/pnas.2306564120. Epub 2023 Jun 20. PMID: 37339228; PMCID: PMC10293834.

Dong Y, Pi X, Bartels-Burgahn F, Saltukoglu D, Liang Z, Yang J, Alt FW, Reth M, Wu H. Structural principles of B cell antigen receptor assembly. Nature. 2022 Dec;612(7938):156-161. doi: 10.1038/s41586-022-05412-7. Epub 2022 Oct 13. PMID: 36228656.

Liang Z, Kumar V, Le Bouteiller M, Zurita J, Kenrick J, Lin SG, Lou J, Hu J, Ye AY, Boboila C, Alt FW, Frock RL. Ku70 suppresses alternative end joining in G1-arrested progenitor B cells. Proc Natl Acad Sci U S A. 2021 May 25;118(21):e2103630118. doi: 10.1073/pnas.2103630118. PMID: 34006647; PMCID: PMC8166026.

Dai HQ, Liang Z, Chang AN, Chapdelaine-Williams AM, Alvarado B, Pollen AA, Alt FW, Schwer B. Direct analysis of brain phenotypes via neural blastocyst complementation. Nat Protoc. 2020 Oct;15(10):3154-3181. doi: 10.1038/s41596-020-0364-y. Epub 2020 Aug 10. PMID: 32778838; PMCID: PMC7685531.

Zhang Y, Zhang X, Ba Z, Liang Z, Dring EW, Hu H, Lou J, Kyritsis N, Zurita J, Shamim MS, Presser Aiden A, Lieberman Aiden E, Alt FW. The fundamental role of chromatin loop extrusion in physiological V(D)J recombination. Nature. 2019 Sep;573(7775):600-604. doi: 10.1038/s41586-019-1547-y. Epub 2019 Sep 11. PMID: 31511698; PMCID: PMC6867615.

Chang AN, Liang Z, Dai HQ, Chapdelaine-Williams AM, Andrews N, Bronson RT, Schwer B, Alt FW. Neural blastocyst complementation enables mouse forebrain organogenesis. Nature. 2018 Nov;563(7729):126-130. doi: 10.1038/s41586-018-0586-0. Epub 2018 Oct 10. PMID: 30305734; PMCID: PMC6588192.

Chen C, Liang Z, Zhou B, Li X, Lui C, Ip NY, Qu JY. In Vivo Near-Infrared Two-Photon Imaging of Amyloid Plaques in Deep Brain of Alzheimer’s Disease Mouse Model. ACS Chem Neurosci. 2018 Dec 19;9(12):3128-3136. doi: 10.1021/acschemneuro.8b00306. Epub 2018 Aug 16. PMID: 30067906.

Huang H, Lin X, Liang Z, Zhao T, Du S, Loy MMT, Lai KO, Fu AKY, Ip NY. Cdk5-dependent phosphorylation of liprinα1 mediates neuronal activity-dependent synapse development. Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):E6992-E7001. doi: 10.1073/pnas.1708240114. Epub 2017 Jul 31. Erratum in: Proc Natl Acad Sci U S A. 2017 Oct 23;: PMID: 28760951; PMCID: PMC5565463.

Liang Z, Zhan Y, Shen Y, Wong CC, Yates JR 3rd, Plattner F, Lai KO, Ip NY. The pseudokinase CaMKv is required for the activity-dependent maintenance of dendritic spines. Nat Commun. 2016 Oct 31;7:13282. doi: 10.1038/ncomms13282. PMID: 27796283; PMCID: PMC5095516.

Liang Z, Ye T, Zhou X, Lai KO, Fu AK, Ip NY. Cdk5 Regulates Activity-Dependent Gene Expression and Dendrite Development. J Neurosci. 2015 Nov 11;35(45):15127-34. doi: 10.1523/JNEUROSCI.1443-15.2015. Erratum in: J Neurosci. 2016 Jan 6;36(1):262. PMID: 26558783; PMCID: PMC6605353.

Lai KO, Liang Z, Fei E, Huang H, Ip NY. Cyclin-dependent Kinase 5 (Cdk5)-dependent Phosphorylation of p70 Ribosomal S6 Kinase 1 (S6K) Is Required for Dendritic Spine Morphogenesis. J Biol Chem. 2015 Jun 5;290(23):14637-46. doi: 10.1074/jbc.M114.627117. Epub 2015 Apr 22. PMID: 25903132; PMCID: PMC4505530.

Chen Y, Liang Z, Fei E, Chen Y, Zhou X, Fang W, Fu WY, Fu AK, Ip NY. Axin Regulates Dendritic Spine Morphogenesis through Cdc42-Dependent Signaling. PLoS One. 2015 Jul 23;10(7):e0133115. doi: 10.1371/journal.pone.0133115. PMID: 26204446; PMCID: PMC4512687.

Lai KO, Wong AS, Cheung MC, Xu P, Liang Z, Lok KC, Xie H, Palko ME, Yung WH, Tessarollo L, Cheung ZH, Ip NY. TrkB phosphorylation by Cdk5 is required for activity-dependent structural plasticity and spatial memory. Nat Neurosci. 2012 Nov;15(11):1506-15. doi: 10.1038/nn.3237. Epub 2012 Oct 14. PMID: 23064382; PMCID: PMC7511999.