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Jun XIA

PhD in Neuroscience

The Johns Hopkins University, 2001

Professor

Thrust of Bioscience and Biomedical Engineering
Division of Life Science

Lab Home Page
E4 L3 318

Personal Web

ResearcherID:

C-7234-2009
Scopus:

56431873500

Google Scholar:

GbjGESIAAAAJ
ORCID:

0000-0001-9308-2188

Biography

Prof. Jun Xia received his medical training in 1993 from Xiangya Medical School of Central South University in China. After obtaining his initial scientific training from the Shanghai Brain Research Institute at Chinese Academy of Sciences, he went to study in the Johns Hopkins University School of Medicine in the United States and received his PhD in Neuroscience in 2001. He joined the Hong Kong University of Science and Technology and has been a faculty member there since 2002. Prof. Xia’s is interested in synapse organization and function with implications in learning, memory and brain disorders. He also works on molecular mechanism of protein trafficking and its implication in diseases. His work identified PICK1 as a key regulator of protein trafficking. PICK1 forms heteromeric BAR domain complexes with ICA69 and regulates AMPA receptor trafficking at synapses, which is important for synapse function. The PICK1-ICA69 complexes also control the biogenesis and maturation of dense core vesicles such as insulin granules and proacrosomal granules. Deficiency of PICK1 in mice led to glucose intolerance and other features resembling diabetes.

Research
Interests

Learning and Memory

Mechanisms of Brain Disorders

Synapse Formation and Function

Protein Trafficking

Publications

Zheng R, Du Y, Wang X, Liao T, Zhang Z, Wang N, Li X, Shen Y, Shi L, Luo J*, Xia J*, Wang Z*, Xu J* (2022). KIF2C regulates synaptic plasticity and cognition in mice through dynamic microtubule depolymerization. eLife 11:e72483.*Co-corresponding authors

He J, Xia M, Yeung PKK, Li J, Li, Z, Chung KK, Chung SK, Xia J* (2018) PICK1 inhibits the E3 ubiquitin ligase activity of Parkin and reduces its neuronal protective effect. PNAS 115(30):E7193-E7201

Wu M, Tian HL, Liu X, Lai JHC, Du S, Xia J* (2018) Impairments of Inhibitory Synapse Formation and Motor Behaviors in Mice Lacking the NL2 Binding Partner LHFPL4/GARLH4. Cell Reports 23:1691-1705.

Xu J, Kam C, Luo J, Xia J*. (2014) PICK1 Mediates Synaptic Recruitment of AMPA Receptors at Neurexin-induced Postsynaptic Sites. Neurosci. 34(46):15415-15424

Cao M, Mao Z, Kam C, Xiao N, Cao X, Shen C, Cheng KKY, Xu A, Lee KM, Jiang L and Xia J* (2013). PICK1 and ICA69 Control Insulin Granule Trafficking and Their Deficiencies Lead to Impaired Glucose Tolerance. PLOS Biology, 11(4): e1001541.

Xu J, Xiao N, Xia J* (2010). Thrombospondin 1 accelerates synaptogenesis in hippocampal neurons through neuroligin 1. Neurosci. 13(1):22-4.

Xiao N, Kam C, Shen C, Jin W, Wang J, Lee KM, Jiang L and Xia J* (2009). PICK1 deficiency causes male infertility in mice by disrupting acrosome formation. Clin Invest. 119(4):802-812.

Pan L, Wu H, Shen C, Shi Y, Jin W, Xia J*and Zhang M* (2007). Clustering and synaptic targeting of PICK1 requires direct interaction between the PDZ domain and lipid membranes. EMBO J. 26(21):4576-87 *Co-corresponding authors.

Cao M, Xu J, Shen C, Kam C, Huganir RL and Xia J* (2007). PICK1-ICA69 heteromeric BAR domain complex regulates synaptic targeting and surface expression of AMPA receptors. Neurosci. 27(47):12945-12956.

Jin W, Ge W, Xu J, Cao M, Peng L, Yung W, Liao D, Duan S, Zhang M and Xia J* (2006). Lipid Binding Regulates PICK1’s Synaptic Targeting, AMPA Receptor Trafficking and Synaptic Plasticity. Neurosci. 26(9):2380-2390

Xia J, Chung HJ, Wihler C, Huganir RL and Linden DJ (2000). Cerebellar Long-Term Depression Requires PKC Regulated Interactions Between GluR2/3 and PDZ Domain-Containing Proteins. Neuron, 28(2):499-510.

Xia J, Zhang X, Staudinger J, Huganir RL. (1999). Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1. Neuron 22(1):179-87.